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ADT-OH improves intestinal barrier function and remodels the gut microbiota in DSS-induced colitis
《医学前沿(英文)》 页码 972-992 doi: 10.1007/s11684-023-0990-1
关键词: inflammatory bowel disease ADT-OH intestinal permeability gut microbiota
Xianyi Zeng,Xiang Zhang,Hao Su,Hongyan Gou,Harry Cheuk-Hay Lau,Xiaoxu Hu,Ziheng Huang,Yan Li,Jun Yu,
《工程(英文)》 doi: 10.1016/j.eng.2022.10.010
关键词: Pien Tze Huang Non-alcoholic steatohepatitis Gut barrier function Gut microbiota
Gut microbial balance and liver transplantation: alteration, management, and prediction
null
《医学前沿(英文)》 2018年 第12卷 第2期 页码 123-129 doi: 10.1007/s11684-017-0563-2
Liver transplantation is a conventional treatment for terminal stage liver diseases. However, several complications still hinder the survival rate. Intestinal barrier destruction is widely observed among patients receiving liver transplant and suffering from ischemia–reperfusion or rejection injuries because of the relationship between the intestine and the liver, both in anatomy and function. Importantly, the resulting alteration of gut microbiota aggravates graft dysfunctions during the process. This article reviews the research progress for gut microbial alterations and liver transplantation. Especially, this work also evaluates research on the management of gut microbial alteration and the prediction of possible injuries utilizing microbial alteration during liver transplantation. In addition, we propose possible directions for research on gut microbial alteration during liver transplantation and offer a hypothesis on the utilization of microbial alteration in liver transplantation. The aim is not only to predict perioperative injuries but also to function as a method of treatment or even inhibit the rejection of liver transplantation.
关键词: gut microbial balance liver transplantation ischemia–reperfusion acute rejection
Integrated analysis of gut microbiome and host immune responses in COVID-19
《医学前沿(英文)》 2022年 第16卷 第2期 页码 263-275 doi: 10.1007/s11684-022-0921-6
Ruiting Han, Junli Ma, Houkai Li
《医学前沿(英文)》 2018年 第12卷 第6期 页码 645-657 doi: 10.1007/s11684-018-0645-9
关键词: gut microbiota NAFLD obesity insulin resistance bile acids probiotic
多组学联用揭示花粉过敏基于肠道菌的新机制 Article
韩珮, 李丽莎, 王子熹, 锡琳, 于航, 丛林, 张正威, 符洁, 彭冉, 潘利斌, 马殊荣, 王学艳, 王洪田, 王向东, 王琰, 孙劲旅, 蒋建东
《工程(英文)》 2022年 第15卷 第8期 页码 115-125 doi: 10.1016/j.eng.2021.03.013
由于过敏性疾病在世界范围内流行且尚无治愈方法,因此有必要探讨其病理生理机制。由于过敏性疾病与肠道菌群失调相关,本研究从宿主与微生物的分子层面,结合代谢组学和微生物组学,寻找可能的机制。本研究对SD大鼠注射青蒿花粉提取物以诱导其对花粉的过敏反应,这种过敏反应降低了血液中的缬氨酸、异亮氨酸、天门冬氨酸、谷氨酸、谷氨酰胺、吲哚丙酸和肌醇浓度,并减少了粪便中的短链脂肪酸(SCFA)。来自于瘤胃球菌科(Ruminococcaceae)、毛螺菌科(Lachnospiraceae)和梭状芽孢杆菌(Clostridiales)的几个有益菌属在模型组中表达减少,而幽门螺杆菌Helicobacter 和阿克曼氏菌Akkermansia 仅在模型组中表达。此外,模型组肠道claudin-3 和肝脏脂肪酸结合蛋白表达下调,与代谢变化和细菌有关。本文的研究结果表明,氨基酸及其衍生物(尤其是缬氨酸和色氨酸的还原产物吲哚丙酸)、短链脂肪酸和肠道微生物(特别是幽门螺杆菌Helicobacter 和阿克曼氏菌Akkermansia)的改变可能通过抑制claudin蛋白表达和影响黏液层而破坏肠道屏障功能,进而导致花粉过敏。
状态受限吸气式高超声速飞行器自适应跟踪控制 Article
Gong-jun LI
《信息与电子工程前沿(英文)》 2017年 第18卷 第5期 页码 599-614 doi: 10.1631/FITEE.1500464
《环境科学与工程前沿(英文)》 2022年 第16卷 第12期 doi: 10.1007/s11783-022-1591-y
● A novel PRB configuration based on passive convergent flow effect was proposed.
关键词: Passive convergence-permeable reactive barrier (PC-PRB) Permeable reactive barrier configuration Numerical simulation Hydraulic performance evaluation Sensitivity analysis
Hydrogen production from methanol through dielectric barrier discharge
Baowei WANG, Xu ZHANG, Haiying BAI, Yijun Lü, Shuanghui HU
《化学科学与工程前沿(英文)》 2011年 第5卷 第2期 页码 209-214 doi: 10.1007/s11705-010-1018-3
Calorie restriction and its impact on gut microbial composition and global metabolism
Xiaojiao Zheng, Shouli Wang, Wei Jia
《医学前沿(英文)》 2018年 第12卷 第6期 页码 634-644 doi: 10.1007/s11684-018-0670-8
Calorie restriction (CR) is a dietary regimen that reduces calorie intake without incurring malnutrition or a reduction in essential nutrients. It has long been recognized as a natural strategy for promoting health, extending longevity, and prevents the development of metabolic and age-related diseases. In the present review, we focus on the general effect of CR on gut microbiota composition and global metabolism. We also propose mechanisms for its beneficial effect. Results showed that probiotic and butyrate-producing microbes increased their relative abundance, whereas proinflammatory strains exhibited suppressed relative abundance following CR. Analyses of the gut microbial and host metabolisms revealed that most host microbial co-metabolites were changed due to CR. Examples of dramatic CR-induced changes in host metabolism included a decrease in the rate of lipid biosynthesis and an increase in the rates of fatty acid catabolism, β-oxidation, glycogenolysis, and gluconeogenesis. The observed phenotypes and the further verification of the direct link between gut microbiota and metabolome may benefit patients that are at risk for developing metabolic disease. Thus, improved gut microbiota composition and metabolome are potential biomarkers for determining the effectiveness of dietary interventions for age-related and metabolic diseases.
《环境科学与工程前沿(英文)》 2023年 第17卷 第11期 doi: 10.1007/s11783-023-1731-z
● A 2D finite-element solute transport model, PRB-Trans, is developed.
关键词: Passive convergence-permeable reactive barrier Numerical modeling Hydraulic behavior assessment Pollutant treatment performance evaluation Influential factors analysis
Degradation of metronidazole by dielectric barrier discharge in an aqueous solution
Zhipeng Yang, Anxing Lai, Hangyu Chen, Youxiang Yan, Ye Yang, Weiwei Zhang, Lei Wang
《环境科学与工程前沿(英文)》 2019年 第13卷 第3期 doi: 10.1007/s11783-019-1117-4
The discharge characteristics during the degradation of MNZ by DBD were investigated. Increasing the discharge frequency can promote the degradation of MNZ. MNZ removal reaches 99.1% at the initial concentration of 40 ppm within 120 min. Coexisting organic matter inhibits the degradation of MNZ. The energy efficiency of DBD for MNZ removal is higher than other technologies.
关键词: Dielectric barrier discharge Antibiotic Metronidazole Water treatment
From gut changes to type 2 diabetes remission after gastric bypass surgeries
null
《医学前沿(英文)》 2013年 第7卷 第2期 页码 191-200 doi: 10.1007/s11684-013-0258-2
Increasing evidence suggests that the gut may influence the host’s metabolism and ultimately change the outcomes of type 2 diabetes mellitus (T2DM). We review the evidence on the relationship between the gut and T2DM remission after gastric bypass surgery, and discuss the potential mechanisms underlying the above relationship: gut anatomical rearrangement, microbial composition changes, altered gut cells, and gut hormone modulation. However, the exact changes and their relative importance in the metabolic improvements after gastric bypass surgery remain to be further clarified. Elucidating the precise metabolic mechanisms of T2DM resolution after bypass surgery will help to reveal the molecular mechanisms of pathogenesis, and facilitate the development of novel diagnoses and preventative interventions for this common disease.
关键词: gastric bypass T2DM gut
Dielectric barrier micro-plasma reactor with segmented outer electrode for decomposition of pure CO
Baowei Wang, Xiaoxi Wang, Bo Zhang
《化学科学与工程前沿(英文)》 2021年 第15卷 第3期 页码 687-697 doi: 10.1007/s11705-020-1974-1
关键词: CO2 decomposition dielectric barrier discharge segmented outer electrodes electrical analysis reactor design
Soumendra Nath KUIRY, Yan DING, Sam S Y WANG
《结构与土木工程前沿(英文)》 2014年 第8卷 第1期 页码 57-68 doi: 10.1007/s11709-014-0235-0
关键词: coastal inlet coastal process modeling supercritical flow sediment transport barrier islands
标题 作者 时间 类型 操作
ADT-OH improves intestinal barrier function and remodels the gut microbiota in DSS-induced colitis
期刊论文
Pien Tze Huang Protects Against Non-Alcoholic Steatohepatitis by Modulating the Gut Microbiota and Metabolites
Xianyi Zeng,Xiang Zhang,Hao Su,Hongyan Gou,Harry Cheuk-Hay Lau,Xiaoxu Hu,Ziheng Huang,Yan Li,Jun Yu,
期刊论文
Mechanistic and therapeutic advances in non-alcoholic fatty liver disease by targeting the gut microbiota
Ruiting Han, Junli Ma, Houkai Li
期刊论文
多组学联用揭示花粉过敏基于肠道菌的新机制
韩珮, 李丽莎, 王子熹, 锡琳, 于航, 丛林, 张正威, 符洁, 彭冉, 潘利斌, 马殊荣, 王学艳, 王洪田, 王向东, 王琰, 孙劲旅, 蒋建东
期刊论文
Passive convergence-permeable reactive barrier (PC-PRB): An effective configuration to enhance hydraulic
期刊论文
Hydrogen production from methanol through dielectric barrier discharge
Baowei WANG, Xu ZHANG, Haiying BAI, Yijun Lü, Shuanghui HU
期刊论文
Calorie restriction and its impact on gut microbial composition and global metabolism
Xiaojiao Zheng, Shouli Wang, Wei Jia
期刊论文
Numerical modeling and performance evaluation of passive convergence-permeable reactive barrier (PC-PRB
期刊论文
Degradation of metronidazole by dielectric barrier discharge in an aqueous solution
Zhipeng Yang, Anxing Lai, Hangyu Chen, Youxiang Yan, Ye Yang, Weiwei Zhang, Lei Wang
期刊论文
Dielectric barrier micro-plasma reactor with segmented outer electrode for decomposition of pure CO
Baowei Wang, Xiaoxi Wang, Bo Zhang
期刊论文